Eicosanoids in sickle cell disease: potential relevance of neutrophil leukotriene B4 to disease pathophysiology
BNY Setty, MJ Stuart - Journal of Laboratory and Clinical Medicine, 2002 - Elsevier
Neutrophil activation with the release of intracellular granule contents has been observed in
sickle cell disease (SCD). Because leukotriene B4 (LTB4), a 5-lipoxygenase metabolite of
arachidonic acid in neutrophils, is a chemoattractant and enhances neutrophil adhesion to
endothelium, we assessed plasma levels of this metabolite in controls (n= 9) and individuals
with SCD, SS genotype, both in basal “steady state”(n= 37) and during episodes of vaso-
occlusion (n= 10) and acute chest syndrome (n= 5). Thirteen patients with SCD, SC …
sickle cell disease (SCD). Because leukotriene B4 (LTB4), a 5-lipoxygenase metabolite of
arachidonic acid in neutrophils, is a chemoattractant and enhances neutrophil adhesion to
endothelium, we assessed plasma levels of this metabolite in controls (n= 9) and individuals
with SCD, SS genotype, both in basal “steady state”(n= 37) and during episodes of vaso-
occlusion (n= 10) and acute chest syndrome (n= 5). Thirteen patients with SCD, SC …