Altered gene expression profiles in nasal respiratory epithelium reflect stable versus acute childhood asthma
JR Guajardo, KW Schleifer, MO Daines… - Journal of allergy and …, 2005 - Elsevier
BACKGROUND: Asthma is the most common chronic disease of childhood and has a strong
genetic component. OBJECTIVE: To identify gene expression signatures that reflect asthma-
related processes and to determine whether these genes were similar or distinct between
stable asthma and acute exacerbations in childhood, we profiled gene expression patterns
in nasal respiratory epithelial cells. METHODS: Children who had stable asthma (asthma-S;
n= 10) and children experiencing an asthma exacerbation (asthma-E; n= 10) were recruited …
genetic component. OBJECTIVE: To identify gene expression signatures that reflect asthma-
related processes and to determine whether these genes were similar or distinct between
stable asthma and acute exacerbations in childhood, we profiled gene expression patterns
in nasal respiratory epithelial cells. METHODS: Children who had stable asthma (asthma-S;
n= 10) and children experiencing an asthma exacerbation (asthma-E; n= 10) were recruited …