Alcohol challenge and sensitivity to change of the Essential Tremor Rating Assessment Scale
B Voller, E Lines, G McCrossin, A Artiles… - Movement …, 2014 - Wiley Online Library
B Voller, E Lines, G McCrossin, A Artiles, S Tinaz, C Lungu, M Hallett, D Haubenberger
Movement Disorders, 2014•Wiley Online LibraryBackground The ability of the Essential Tremor (ET) Rating Assessment Scale (TETRAS) to
detect changes in tremor severity is unknown. Methods Fifteen adult ET patients received a
single oral ethanol dose calculated to reach 0.05 g/dL breath alcohol content (brAC). Effects
were investigated independently with accelerometry and TETRAS. Results Accelerometry
data were log‐transformed and a cumulative score logACC (R+ L) was calculated.
Correlation between logACC (R+ L) and TETRAS was significant. TETRAS and …
detect changes in tremor severity is unknown. Methods Fifteen adult ET patients received a
single oral ethanol dose calculated to reach 0.05 g/dL breath alcohol content (brAC). Effects
were investigated independently with accelerometry and TETRAS. Results Accelerometry
data were log‐transformed and a cumulative score logACC (R+ L) was calculated.
Correlation between logACC (R+ L) and TETRAS was significant. TETRAS and …
Background
The ability of the Essential Tremor (ET) Rating Assessment Scale (TETRAS) to detect changes in tremor severity is unknown.
Methods
Fifteen adult ET patients received a single oral ethanol dose calculated to reach 0.05 g/dL breath alcohol content (brAC). Effects were investigated independently with accelerometry and TETRAS.
Results
Accelerometry data were log‐transformed and a cumulative score logACC(R+L) was calculated. Correlation between logACC(R+L) and TETRAS was significant. TETRAS and accelerometry showed a significant effect of time point using repeated‐measures analysis of variance. The difference between baseline and each of the following six time points as well as the correlation of TETRAS with brAC were significant. The calculated minimum detectable change of TETRAS was 8.9% and the effect size was d = 4.75 (95% confidence interval: 3.60–5.90).
Conclusion
We demonstrated sensitivity to change of the TETRAS performance scale after a therapeutic intervention, which further establishes its potential for use in both clinical and research settings. © 2013 International Parkinson and Movement Disorder Society
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