Cytokines in the pathogenesis of influenza

K Van Reeth - Veterinary microbiology, 2000 - Elsevier
Uncomplicated influenza in humans, horses or swine is characterized by massive virus
replication in respiratory epithelial cells, inflammation and an abrupt onset of general and
respiratory disease. There is now growing evidence that the so-called early cytokines
produced at the site of infection mediate many of the clinical and pathological
manifestations. Among these cytokines are interferon-α (IFN-α), tumour necrosis factor-α
(TNF-α), interleukin-1 (IL-1) α and β, interleukin-6 (IL-6), interleukin-8 (IL-8) and monocyte …