[HTML][HTML] P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration

T Yamagishi, S Sahni, DM Sharp, A Arvind… - Journal of Biological …, 2013 - ASBMB
Localization of the drug transporter P-glycoprotein (Pgp) to the plasma membrane is thought
to be the only contributor of Pgp-mediated multidrug resistance (MDR). However, very little
work has focused on the contribution of Pgp expressed in intracellular organelles to drug
resistance. This investigation describes an additional mechanism for understanding how
lysosomal Pgp contributes to MDR. These studies were performed using Pgp-expressing
MDR cells and their non-resistant counterparts. Using confocal microscopy and lysosomal …