Physiological consequences of loss of plasminogen activator gene function in mice

P Carmeliet, L Schoonjans, L Kieckens, B Ream… - Nature, 1994 - nature.com
P Carmeliet, L Schoonjans, L Kieckens, B Ream, J Degen, R Bronson, R De Vos…
Nature, 1994nature.com
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological
triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many
proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-
PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA
deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on
growth, fertility and survival.
Abstract
Indirect evidence suggests a crucial role for the fibrinolytic system and its physiological triggers, tissue-type (t-PA) and urokinase-type (u-PA) plasminogen activator, in many proteolytic processes. Inactivation of the t-PA gene impairs clot lysis and inactivation of the u-PA gene results in occasional fibrin deposition. Mice with combined t-PA and u-PA deficiency suffer extensive spontaneous fibrin deposition, with its associated effects on growth, fertility and survival.
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