Detection, evaluation, and management of iron-restricted erythropoiesis

LT Goodnough, E Nemeth… - Blood, The Journal of the …, 2010 - ashpublications.org
Blood, The Journal of the American Society of Hematology, 2010ashpublications.org
Progress in our understanding of iron-restricted erythropoiesis has been made possible by
important advances in defining the molecular mechanisms of iron homeostasis. The
detection and diagnostic classification of iron-restricted erythropoiesis can be a challenging
process for the clinician. Newer assays for markers of inflammation may allow more targeted
management of the anemia in these conditions. The availability of new intravenous iron
preparations provides new options for the treatment of iron-restricted erythropoiesis. This …
Abstract
Progress in our understanding of iron-restricted erythropoiesis has been made possible by important advances in defining the molecular mechanisms of iron homeostasis. The detection and diagnostic classification of iron-restricted erythropoiesis can be a challenging process for the clinician. Newer assays for markers of inflammation may allow more targeted management of the anemia in these conditions. The availability of new intravenous iron preparations provides new options for the treatment of iron-restricted erythropoiesis. This review summarizes recent advances regarding the detection, evaluation, and management of iron-restricted erythropoiesis.
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