Role of the programmed Death-1 pathway in the suppressive activity of alternatively activated macrophages in experimental cysticercosis

LI Terrazas, D Montero, CA Terrazas, JL Reyes… - International journal for …, 2005 - Elsevier
We characterised a population of macrophages potentially involved in the immunoregulation
induced by experimental cysticercosis. Following Taenia crassiceps infection, macrophages
recruited in the peritoneal cavity were isolated and co-cultured at different ratios with T cells
from naïve mice previously stimulated with anti-CD3/CD28 antibodies; these macrophages
inhibited naïve T cell proliferation. This suppressive effect was Interleukin (IL)-10, Interferon-
gamma (IFN-γ), and nitric oxide (NO) independent. In contrast, macrophage-T cell contact …