[HTML][HTML] Lymphangiogenic factors, mechanisms, and applications

W Zheng, A Aspelund, K Alitalo - The Journal of clinical …, 2014 - Am Soc Clin Investig
W Zheng, A Aspelund, K Alitalo
The Journal of clinical investigation, 2014Am Soc Clin Investig
Lymphangiogenesis, the growth of lymphatic vessels, is essential in embryonic
development. In adults, it is involved in many pathological processes such as lymphedema,
inflammatory diseases, and tumor metastasis. Advances during the past decade have
dramatically increased the knowledge of the mechanisms of lymphangiogenesis, including
the roles of transcription factors, lymphangiogenic growth factors and their receptors, and
intercellular and intracellular signaling cascades. Strategies based on these mechanisms …
Lymphangiogenesis, the growth of lymphatic vessels, is essential in embryonic development. In adults, it is involved in many pathological processes such as lymphedema, inflammatory diseases, and tumor metastasis. Advances during the past decade have dramatically increased the knowledge of the mechanisms of lymphangiogenesis, including the roles of transcription factors, lymphangiogenic growth factors and their receptors, and intercellular and intracellular signaling cascades. Strategies based on these mechanisms are being tested in the treatment of various human diseases such as cancer, lymphedema, and tissue allograft rejection. This Review summarizes the recent progress on lymphangiogenic mechanisms and their applications in disease treatment.
The Journal of Clinical Investigation