MicroRNA in pulmonary vascular disease

AMK Rothman, TJA Chico, A Lawrie - Progress in molecular biology and …, 2014 - Elsevier
MicroRNA (miRNA) are short noncoding RNA that regulate gene expression by inhibiting
translation or promoting degradation of target mRNA. miRNA are key regulators of a wide
range of cellular processes and their discovery has revolutionized our understanding of
gene regulatory networks. Pulmonary arterial hypertension (PAH) is a debilitating and fatal
disease characterized by remodeling of pulmonary arteries and right heart failure. Factors
including sustained pulmonary vasoconstriction, inflammation, and altered cellular signaling …