Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial
ML Furey, WC Drevets - Archives of general psychiatry, 2006 - jamanetwork.com
Context The need for improved therapeutic agents that more quickly and effectively treat
depression is critical. In a pilot study we evaluated the role of the cholinergic system in
cognitive symptoms of depression and unexpectedly observed rapid reductions in
depression severity following the administration of the antimuscarinic drug scopolamine
hydrobromide (4 μg/kg intravenously) compared with placebo (P=. 002). Subsequently a
clinical trial was designed to assess more specifically the antidepressant efficacy of …
depression is critical. In a pilot study we evaluated the role of the cholinergic system in
cognitive symptoms of depression and unexpectedly observed rapid reductions in
depression severity following the administration of the antimuscarinic drug scopolamine
hydrobromide (4 μg/kg intravenously) compared with placebo (P=. 002). Subsequently a
clinical trial was designed to assess more specifically the antidepressant efficacy of …