[HTML][HTML] Altered glucose homeostasis in mice with liver-specific deletion of Src homology phosphatase 2

K Matsuo, M Delibegovic, I Matsuo, N Nagata… - Journal of biological …, 2010 - ASBMB
The Src homology 2 domain-containing protein-tyrosine phosphatase Shp2 has been
implicated in a variety of growth factor signaling pathways, but its role in insulin signaling
has remained unresolved. In vitro studies suggest that Shp2 is both a negative and positive
regulator of insulin signaling, although its physiological function in a number of peripheral
insulin-responsive tissues remains unknown. To address the metabolic role of Shp2 in the
liver, we generated mice with either chronic or acute hepatic Shp2 deletion using tissue …