[HTML][HTML] Coexpression of donor peptide/recipient MHC complex and intact donor MHC: evidence for a link between the direct and indirect pathways
K Brown, SH Sacks, W Wong - American Journal of Transplantation, 2011 - Elsevier
T lymphocytes recognize foreign antigens presented by donor or recipient cells through the
direct and indirect pathways respectively. This raises the question of how directly and
indirectly activated T cells interact. A 4-cell model involving the interaction of CD4+ and
CD8+ T cells recognizing major histocompatibility complex (MHC) class II on recipient
antigen presenting cell (APC), and MHC class I on donor APC, has been proposed.
However, this would require complex co-ordination between all the participating cell types …
direct and indirect pathways respectively. This raises the question of how directly and
indirectly activated T cells interact. A 4-cell model involving the interaction of CD4+ and
CD8+ T cells recognizing major histocompatibility complex (MHC) class II on recipient
antigen presenting cell (APC), and MHC class I on donor APC, has been proposed.
However, this would require complex co-ordination between all the participating cell types …