[HTML][HTML] Negative reinforcement reveals non-evoked ongoing pain in mice with tissue or nerve injury
Y He, X Tian, X Hu, F Porreca, ZJ Wang - The Journal of Pain, 2012 - Elsevier
Patients with chronic pain experience spontaneous or ongoing pain as well as enhanced
sensitivity to evoked stimuli. Spontaneous or ongoing pain is rarely evaluated in preclinical
studies. In fact, it remains controversial whether ongoing or spontaneous pain even
develops in mice after tissue or nerve injury. This study tested a hypothesis that negative
reinforcement can be used to unmask the presence of pain in mice with tissue or nerve
injury. We found that spinal administration of clonidine or lidocaine did not elicit conditioned …
sensitivity to evoked stimuli. Spontaneous or ongoing pain is rarely evaluated in preclinical
studies. In fact, it remains controversial whether ongoing or spontaneous pain even
develops in mice after tissue or nerve injury. This study tested a hypothesis that negative
reinforcement can be used to unmask the presence of pain in mice with tissue or nerve
injury. We found that spinal administration of clonidine or lidocaine did not elicit conditioned …