The inhibitor of phagocytosis, O-phospho-L-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina
TJ Bailey, SL Fossum, SM Fimbel… - Experimental eye …, 2010 - Elsevier
The damaged zebrafish retina replaces lost neurons through a regenerative response that
initiates with the asymmetric cell division of Müller glia to produce neuronal progenitor cells
that proliferate and migrate to the damaged retinal layer, where they differentiate into the lost
neuronal cell types. Because Müller glia are known to phagocytose apoptotic retinal cells
during development, we tested if Müller glia engulfed apoptotic rod cell bodies in light-
damaged retinas. After 24h of constant intense light, damaged retinas revealed both a …
initiates with the asymmetric cell division of Müller glia to produce neuronal progenitor cells
that proliferate and migrate to the damaged retinal layer, where they differentiate into the lost
neuronal cell types. Because Müller glia are known to phagocytose apoptotic retinal cells
during development, we tested if Müller glia engulfed apoptotic rod cell bodies in light-
damaged retinas. After 24h of constant intense light, damaged retinas revealed both a …