Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapy

E Connick, MA Kane, IE White, J Ryder… - Clinical infectious …, 2004 - academic.oup.com
E Connick, MA Kane, IE White, J Ryder, TB Campbell
Clinical infectious diseases, 2004academic.oup.com
Rapidly progressive Kaposi sarcoma (KS) lesions with lymphadenopathy and tissue
swelling occurred in a patient during antiretroviral treatment, despite an increased CD4+
lymphocyte count and decreased HIV-1 level and KS-associated herpesvirus replication,
suggesting immune reconstitution inflammatory syndrome. Inflammation resolved coincident
with decreases in the CD4+ lymphocyte count during paclitaxel treatment, whereas KS
cleared only after prolonged antiretroviral therapy and chemotherapy.
Abstract
Rapidly progressive Kaposi sarcoma (KS) lesions with lymphadenopathy and tissue swelling occurred in a patient during antiretroviral treatment, despite an increased CD4+ lymphocyte count and decreased HIV-1 level and KS-associated herpesvirus replication, suggesting immune reconstitution inflammatory syndrome. Inflammation resolved coincident with decreases in the CD4+ lymphocyte count during paclitaxel treatment, whereas KS cleared only after prolonged antiretroviral therapy and chemotherapy.
Oxford University Press