[HTML][HTML] Kaposi sarcoma-associated herpesvirus degrades cellular Toll-interleukin-1 receptor domain-containing adaptor-inducing β-interferon (TRIF)
H Ahmad, R Gubbels, E Ehlers, F Meyer… - Journal of biological …, 2011 - ASBMB
Kaposi sarcoma-associated herpesvirus (KSHV) is a human γ-herpesvirus associated with
several human malignancies. The replication and transcription activator (RTA) is necessary
and sufficient for the switch from KSHV latency to lytic replication. Toll-interleukin-1 receptor
(TIR) domain-containing adaptor-inducing β-interferon (TRIF, also called TIR-domain-
containing adaptor molecule-1 (TICAM-1)) is a signaling adaptor molecule that is critically
involved in the Toll-like receptor 3 (TLR-3) and TLR-4 signaling pathways for type I …
several human malignancies. The replication and transcription activator (RTA) is necessary
and sufficient for the switch from KSHV latency to lytic replication. Toll-interleukin-1 receptor
(TIR) domain-containing adaptor-inducing β-interferon (TRIF, also called TIR-domain-
containing adaptor molecule-1 (TICAM-1)) is a signaling adaptor molecule that is critically
involved in the Toll-like receptor 3 (TLR-3) and TLR-4 signaling pathways for type I …