Inhibition of neutrophil function by the Kaposi's sarcoma-associated herpesvirus vOX2 protein
SAR Rezaee, JA Gracie, IB McInnes, DJ Blackbourn - Aids, 2005 - journals.lww.com
SAR Rezaee, JA Gracie, IB McInnes, DJ Blackbourn
Aids, 2005•journals.lww.comKaposi's sarcoma is multifactorial, involving Kaposi's sarcoma-associated herpesvirus
(KSHV) infection and immune dysfunction. A KSHV protein (vOX2), fused with the Fc domain
of human immunoglobulin G 1 to create vOX2: Fc, suppressed neutrophil oxidative burst and
inhibited the production of pro-inflammatory chemokines (IL-8 and monocyte
chemoattractant protein 1) by monocyte/macrophage cells. vOX2: Fc suppressed the acute
inflammatory response in mice in which neutrophil-mediated inflammation was induced by …
(KSHV) infection and immune dysfunction. A KSHV protein (vOX2), fused with the Fc domain
of human immunoglobulin G 1 to create vOX2: Fc, suppressed neutrophil oxidative burst and
inhibited the production of pro-inflammatory chemokines (IL-8 and monocyte
chemoattractant protein 1) by monocyte/macrophage cells. vOX2: Fc suppressed the acute
inflammatory response in mice in which neutrophil-mediated inflammation was induced by …
Abstract
Kaposi's sarcoma is multifactorial, involving Kaposi's sarcoma-associated herpesvirus (KSHV) infection and immune dysfunction. A KSHV protein (vOX2), fused with the Fc domain of human immunoglobulin G 1 to create vOX2: Fc, suppressed neutrophil oxidative burst and inhibited the production of pro-inflammatory chemokines (IL-8 and monocyte chemoattractant protein 1) by monocyte/macrophage cells. vOX2: Fc suppressed the acute inflammatory response in mice in which neutrophil-mediated inflammation was induced by carrageenan. The data suggest that vOX2 can contribute to immune dysfunction and could have anti-inflammatory therapeutic potential.
Lippincott Williams & Wilkins