Overexpression of epidermal growth factor receptor restricted to macrophages in uveal melanoma
AGM Scholes, S Hagan, P Hiscott… - Archives of …, 2001 - jamanetwork.com
Objective To determine whether expression of the epidermal growth factor receptor (EGFR)
is of prognostic value in uveal melanoma. Methods Thirty consecutive patients treated for
primary posterior uveal melanoma by enucleation or local resection were studied. Tumors
were examined for EGFR and CD68 expression by immunohistochemistry on formalin-fixed,
paraffin-embedded sections. Extracted DNA from paired frozen tumor and blood samples
was examined for loss of heterozygosity on chromosome 3 using polymerase chain reaction …
is of prognostic value in uveal melanoma. Methods Thirty consecutive patients treated for
primary posterior uveal melanoma by enucleation or local resection were studied. Tumors
were examined for EGFR and CD68 expression by immunohistochemistry on formalin-fixed,
paraffin-embedded sections. Extracted DNA from paired frozen tumor and blood samples
was examined for loss of heterozygosity on chromosome 3 using polymerase chain reaction …