[HTML][HTML] Transient suppression of ligand-mediated activation of epidermal growth factor receptor by tumor necrosis factor-α through the TAK1-p38 signaling pathway
P Singhirunnusorn, Y Ueno, M Matsuo, S Suzuki… - Journal of biological …, 2007 - ASBMB
Epidermal growth factor receptor (EGFR) has been shown to be activated by specific ligands
as well as other cellular stimuli including tumor necrosis factor-α (TNF-α). In the present
study, we found that cellular stress suppressed ligand-mediated EGFR activity. Both TNF-α
and osmotic stress rapidly induced phosphorylation of EGFR. This phosphorylation of EGFR
and the activation of mitogen-activated protein kinases and NF-κB occurred independently
of the shedding of extracellular membrane-bound EGFR ligands and intracellular EGFR …
as well as other cellular stimuli including tumor necrosis factor-α (TNF-α). In the present
study, we found that cellular stress suppressed ligand-mediated EGFR activity. Both TNF-α
and osmotic stress rapidly induced phosphorylation of EGFR. This phosphorylation of EGFR
and the activation of mitogen-activated protein kinases and NF-κB occurred independently
of the shedding of extracellular membrane-bound EGFR ligands and intracellular EGFR …