Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation
T Fukuda, T Yoshida, S Okada, M Hatano… - The Journal of …, 1997 - rupress.org
T Fukuda, T Yoshida, S Okada, M Hatano, T Miki, K Ishibashi, S Okabe, H Koseki…
The Journal of experimental medicine, 1997•rupress.orgThe Bcl6 gene has been identified from the chromosomal translocation breakpoint in B cell
lymphomas, and its products are expressed highly in germinal center (GC) B cells. To
investigate the function of Bcl6 in lymphocytes, we have generated RAG1-deficient mice
reconstituted with bone marrow cells from Bcl6-deficient mice (Bcl6−/− RM). Lymphogenesis
in primary lymphoid tissues of Bcl6−/− RM is normal, and Bcl6−/− RM produced control
levels of primary IgG1 antibodies specific to T cell–dependent antigens. However, GCs were …
lymphomas, and its products are expressed highly in germinal center (GC) B cells. To
investigate the function of Bcl6 in lymphocytes, we have generated RAG1-deficient mice
reconstituted with bone marrow cells from Bcl6-deficient mice (Bcl6−/− RM). Lymphogenesis
in primary lymphoid tissues of Bcl6−/− RM is normal, and Bcl6−/− RM produced control
levels of primary IgG1 antibodies specific to T cell–dependent antigens. However, GCs were …
The Bcl6 gene has been identified from the chromosomal translocation breakpoint in B cell lymphomas, and its products are expressed highly in germinal center (GC) B cells. To investigate the function of Bcl6 in lymphocytes, we have generated RAG1-deficient mice reconstituted with bone marrow cells from Bcl6-deficient mice (Bcl6−/−RM). Lymphogenesis in primary lymphoid tissues of Bcl6−/−RM is normal, and Bcl6−/−RM produced control levels of primary IgG1 antibodies specific to T cell–dependent antigens. However, GCs were not found in these mice. This defect was mainly due to the abnormalities of B cells. Therefore, Bcl6 is essential for the differentiation of GC B cells.
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