[PDF][PDF] Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation

A Chaudhry, RM Samstein, P Treuting, Y Liang… - Immunity, 2011 - cell.com
A Chaudhry, RM Samstein, P Treuting, Y Liang, MC Pils, JM Heinrich, RS Jack…
Immunity, 2011cell.com
Effector CD4+ T cell subsets, whose differentiation is facilitated by distinct cytokine cues,
amplify the corresponding type of inflammatory response. Regulatory T (Treg) cells integrate
environmental cues to suppress particular types of inflammation. In this regard, STAT3, a
transcription factor essential for T helper 17 (Th17) cell differentiation, is necessary for Treg
cell-mediated control of Th17 cell responses. Here, we showed that anti-inflammatory
interleukin-10 (IL-10), and not proinflammatory IL-6 and IL-23 cytokine signaling, endowed …
Summary
Effector CD4+ T cell subsets, whose differentiation is facilitated by distinct cytokine cues, amplify the corresponding type of inflammatory response. Regulatory T (Treg) cells integrate environmental cues to suppress particular types of inflammation. In this regard, STAT3, a transcription factor essential for T helper 17 (Th17) cell differentiation, is necessary for Treg cell-mediated control of Th17 cell responses. Here, we showed that anti-inflammatory interleukin-10 (IL-10), and not proinflammatory IL-6 and IL-23 cytokine signaling, endowed Treg cells with the ability to suppress pathogenic Th17 cell responses. Ablation of the IL-10 receptor in Treg cells resulted in selective dysregulation of Th17 cell responses and colitis similar to that observed in mice harboring STAT3-deficient Treg cells. Thus, Treg cells limit Th17 cell inflammation by serving as principal amplifiers of negative regulatory circuits operating in immune effector cells.
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