The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly

KD Mirchandani, RM McCaffrey, AD D'Andrea - DNA repair, 2008 - Elsevier
Fanconi anemia (FA) is a chromosome instability syndrome characterized by congenital
abnormalities, cellular hypersensitivity to DNA crosslinking agents, and heightened cancer
risk. Eight of the thirteen identified FA genes encode subunits of a nuclear FA core complex
that monoubiquitinates FANCD2 and FANCI to maintain genomic stability in response to
replication stress. The FA pathway has been implicated in the regulation of error-prone DNA
damage tolerance via an undefined molecular mechanism. Here, we show that the FA core …