[HTML][HTML] Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the …
RJ Phillips, J Mestas, M Gharaee-Kermani… - Journal of Biological …, 2005 - ASBMB
Non-small cell lung cancer (NSCLC) expresses a particularly aggressive metastatic
phenotype, and patients with this disease have a poor prognosis. CXC chemokine receptor
4 (CXCR4) is a cell surface receptor that has been shown to mediate the metastasis of many
solid tumors including lung, breast, kidney, and prostate. In addition, overexpression of the
epidermal growth factor receptor (EGFR) is associated with the majority of NSCLC and has
been implicated in the process of malignant transformation by promoting cell proliferation …
phenotype, and patients with this disease have a poor prognosis. CXC chemokine receptor
4 (CXCR4) is a cell surface receptor that has been shown to mediate the metastasis of many
solid tumors including lung, breast, kidney, and prostate. In addition, overexpression of the
epidermal growth factor receptor (EGFR) is associated with the majority of NSCLC and has
been implicated in the process of malignant transformation by promoting cell proliferation …