Mechanism of action of 2-methoxyestradiol: new developments
SL Mooberry - Drug Resistance Updates, 2003 - Elsevier
2-Methoxyestradiol (2ME2) is an endogenous metabolite of estrogen that has both
antiangiogenic and antitumor effects. In preclinical models, 2ME2 showed promising activity
that led to its clinical development as an orally active, small-molecule inhibitor of
angiogenesis. Initial results suggest that 2ME2 is well tolerated and several Phase I and II
clinical trials are evaluating 2ME2 in multiple tumor types. While many studies over the past
10 years have increased our understanding of how 2ME2 exerts its pleiotropic effects, its …
antiangiogenic and antitumor effects. In preclinical models, 2ME2 showed promising activity
that led to its clinical development as an orally active, small-molecule inhibitor of
angiogenesis. Initial results suggest that 2ME2 is well tolerated and several Phase I and II
clinical trials are evaluating 2ME2 in multiple tumor types. While many studies over the past
10 years have increased our understanding of how 2ME2 exerts its pleiotropic effects, its …