[HTML][HTML] Hypoxia potentiates palmitate-induced pro-inflammatory activation of primary human macrophages
RG Snodgrass, M Boß, E Zezina, A Weigert… - Journal of Biological …, 2016 - ASBMB
Pro-inflammatory cytokines secreted by adipose tissue macrophages (ATMs) contribute to
chronic low-grade inflammation and obesity-induced insulin resistance. Recent studies have
shown that adipose tissue hypoxia promotes an inflammatory phenotype in ATMs. However,
our understanding of how hypoxia modulates the response of ATMs to free fatty acids within
obese adipose tissue is limited. We examined the effects of hypoxia (1% O 2) on the pro-
inflammatory responses of human monocyte-derived macrophages to the saturated fatty …
chronic low-grade inflammation and obesity-induced insulin resistance. Recent studies have
shown that adipose tissue hypoxia promotes an inflammatory phenotype in ATMs. However,
our understanding of how hypoxia modulates the response of ATMs to free fatty acids within
obese adipose tissue is limited. We examined the effects of hypoxia (1% O 2) on the pro-
inflammatory responses of human monocyte-derived macrophages to the saturated fatty …