More alternative activation of macrophages in lungs of asthmatic patients
BN Melgert, NH ten Hacken, B Rutgers… - Journal of Allergy and …, 2011 - jacionline.org
To the Editor: The innate immune system is increasingly being associated with asthma
induction and progression. 1, 2 Macrophages are an important part of the innate immune
system, but their contribution to asthma pathogenesis is not clear. 3 Recent articles have
associated markers of the alternatively activated phenotype of macrophages (aaMFs) with
asthma. 4, 5 This alternatively activated phenotype develops after exposure to IL-4, IL-13, or
both, and it is therefore not surprising that markers of alternative activation, such as AMCase …
induction and progression. 1, 2 Macrophages are an important part of the innate immune
system, but their contribution to asthma pathogenesis is not clear. 3 Recent articles have
associated markers of the alternatively activated phenotype of macrophages (aaMFs) with
asthma. 4, 5 This alternatively activated phenotype develops after exposure to IL-4, IL-13, or
both, and it is therefore not surprising that markers of alternative activation, such as AMCase …