[HTML][HTML] Insulin-like growth factor-I prevents the accumulation of autophagic vesicles and cell death in Purkinje neurons by increasing the rate of autophagosome-to …

M Bains, ML Florez-McClure, KA Heidenreich - Journal of biological …, 2009 - ASBMB
Continuous macroautophagic activity is critical for the maintenance of neuronal
homeostasis; however, unchecked or dysregulated autophagy can lead to cell death.
Cultured Purkinje neurons die by an autophagy-associated cell death mechanism when
deprived of trophic support. Here, we report that insulin-like growth factor-I (IGF-I) completely
blocked the autophagy-associated cell death of Purkinje neurons. To examine the
mechanism by which IGF-I influences autophagy, neurons were infected with adeno-RFP …