[HTML][HTML] An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis
RM Crooke, MJ Graham, KM Lemonidis… - Journal of lipid …, 2005 - ASBMB
High levels of plasma apolipoprotein B-100 (apoB-100), the principal apolipoprotein of LDL,
are associated with cardiovascular disease. We hypothesized that suppression of apoB-100
mRNA by an antisense oligonucleotide (ASO) would reduce LDL cholesterol (LDL-C).
Because most of the plasma apoB is made in the liver, and antisense drugs distribute to that
organ, we tested the effects of a mouse-specific apoB-100 ASO in several mouse models of
hyperlipidemia, including C57BL/6 mice fed a high-fat diet, Apoe-deficient mice, and Ldlr …
are associated with cardiovascular disease. We hypothesized that suppression of apoB-100
mRNA by an antisense oligonucleotide (ASO) would reduce LDL cholesterol (LDL-C).
Because most of the plasma apoB is made in the liver, and antisense drugs distribute to that
organ, we tested the effects of a mouse-specific apoB-100 ASO in several mouse models of
hyperlipidemia, including C57BL/6 mice fed a high-fat diet, Apoe-deficient mice, and Ldlr …