Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers

J Bussink, JHAM Kaanders, AJ van der Kogel - Radiotherapy and Oncology, 2003 - Elsevier
Background and purpose: Tumor oxygenation is recognized as an important determinant of
the outcome of radiotherapy and possibly also of other treatment modalities in a number of
tumor types and in particular in squamous cell carcinomas. The hypoxic status of various
solid tumors has been related to a poor prognosis due to tumor progression towards a more
malignant phenotype, with increased metastatic potential, and an increased resistance to
treatment. It has been demonstrated in head and neck cancer that hypoxic radioresistance …