[HTML][HTML] Biological consequences of radiation-induced DNA damage: relevance to radiotherapy
ME Lomax, LK Folkes, P O'neill - Clinical oncology, 2013 - Elsevier
DNA damage of exposed tumour tissue leading to cell death is one of the detrimental effects
of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The
pattern of the discrete energy depositions during passage of the ionising track of radiation
defines the spatial distribution of lesions induced in DNA with a fraction of the DNA damage
sites containing clusters of lesions, formed over a few nanometres, against a background of
endogenously induced individual lesions. These clustered DNA damage sites, which may …
of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The
pattern of the discrete energy depositions during passage of the ionising track of radiation
defines the spatial distribution of lesions induced in DNA with a fraction of the DNA damage
sites containing clusters of lesions, formed over a few nanometres, against a background of
endogenously induced individual lesions. These clustered DNA damage sites, which may …