[HTML][HTML] The role of HIF-1α in transcriptional regulation of the proximal tubular epithelial cell response to hypoxia
MO Leonard, DC Cottell, C Godson, HR Brady… - Journal of Biological …, 2003 - ASBMB
Epithelial cells of the kidney represent a primary target for hypoxic injury in ischemic acute
renal failure (ARF); however, the underlying transcriptional mechanism (s) remain
undefined. In this study, human proximal tubular epithelial cells (HK-2) exposed to hypoxia
in vitro demonstrated a non-lethal but dysfunctional phenotype, closely reflective of the
epithelial pathobiology of ARF. HK-2 cells exposed to hypoxia demonstrated increased
paracellular permeability, decreased proliferation, loss of tight junctional integrity, and …
renal failure (ARF); however, the underlying transcriptional mechanism (s) remain
undefined. In this study, human proximal tubular epithelial cells (HK-2) exposed to hypoxia
in vitro demonstrated a non-lethal but dysfunctional phenotype, closely reflective of the
epithelial pathobiology of ARF. HK-2 cells exposed to hypoxia demonstrated increased
paracellular permeability, decreased proliferation, loss of tight junctional integrity, and …