[HTML][HTML] Hypoxia-inducible factor 1 in dendritic cells is crucial for the activation of protective regulatory T cells in murine colitis
K Flück, G Breves, J Fandrey, S Winning - Mucosal immunology, 2016 - Elsevier
Dendritic cells (DCs) serve as a bridge between innate and adaptive immunity and help to
maintain intestinal homeostasis. Inflammatory bowel disease (IBD) is associated with
dysregulation of the mucosal immune response. The concomitant hypoxic inflammation in
IBD will activate the transcription factor hypoxia-inducible factor-1 (HIF-1) to also drive gene
expression in DCs. Recent studies have described a protective role for epithelial HIF-1 in
mouse models of IBD. We investigated the role of HIF-1 in DC function in a dextran sodium …
maintain intestinal homeostasis. Inflammatory bowel disease (IBD) is associated with
dysregulation of the mucosal immune response. The concomitant hypoxic inflammation in
IBD will activate the transcription factor hypoxia-inducible factor-1 (HIF-1) to also drive gene
expression in DCs. Recent studies have described a protective role for epithelial HIF-1 in
mouse models of IBD. We investigated the role of HIF-1 in DC function in a dextran sodium …