Kinase/phosphatase balance governs cardiac excitability in health and disease. Although
detailed mechanisms for cardiac kinase regulation are established, far less is known
regarding cardiac protein phosphatase 2A (PP2A) regulation. This is largely due to the
complexity of the PP2A holoenzyme structure (combinatorial assembly of three subunit
enzyme from> 17 subunit genes) and the inability to segregate" global" PP2A function from
the activities of multiple" local" holoenzyme populations. Here we report that PP2A catalytic …