[HTML][HTML] Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A: activation is stereospecific and regulated by phosphatidic acid
CE Chalfant, K Kishikawa, MC Mumby… - Journal of Biological …, 1999 - ASBMB
The search for potential targets for ceramide action led to the identification of ceramide-
activated protein phosphatases, which include protein phosphatase-2A (PP2A) and protein
phosphatase-1 (PP1) with roles in regulating apoptosis and cell growth. Thus far, in vitro
studies on ceramide-activated protein phosphatases have been restricted to the use of short
chain ceramides, limiting the extent of mechanistic insight. In this study, we show that the
long chaind-erythro-C 18-ceramide activated PP2A (AB′ C trimer), PP2Ac (catalytic subunit …
activated protein phosphatases, which include protein phosphatase-2A (PP2A) and protein
phosphatase-1 (PP1) with roles in regulating apoptosis and cell growth. Thus far, in vitro
studies on ceramide-activated protein phosphatases have been restricted to the use of short
chain ceramides, limiting the extent of mechanistic insight. In this study, we show that the
long chaind-erythro-C 18-ceramide activated PP2A (AB′ C trimer), PP2Ac (catalytic subunit …