[HTML][HTML] Hepatic de novo lipogenesis in normoinsulinemic and hyperinsulinemic subjects consuming high-fat, low-carbohydrate and low-fat, high-carbohydrate …
JM Schwarz, P Linfoot, D Dare, K Aghajanian - The American journal of …, 2003 - Elsevier
Background: Hypertriglyceridemia is associated with increased risk of cardiovascular
disease. Until recently, the importance of hepatic de novo lipogenesis (DNL) in contributing
to hypertriglyceridemia was difficult to assess because of methodologic limitations.
Objective: We evaluated the extent of the contribution by DNL to different conditions
associated with hypertriglyceridemia. Design: After 5 d of an isoenergetic high-fat, low-
carbohydrate diet, fasting DNL was measured in normoinsulinemic (≤ 85 pmol/L) lean (n …
disease. Until recently, the importance of hepatic de novo lipogenesis (DNL) in contributing
to hypertriglyceridemia was difficult to assess because of methodologic limitations.
Objective: We evaluated the extent of the contribution by DNL to different conditions
associated with hypertriglyceridemia. Design: After 5 d of an isoenergetic high-fat, low-
carbohydrate diet, fasting DNL was measured in normoinsulinemic (≤ 85 pmol/L) lean (n …