[HTML][HTML] ChREBP• Mlx is the principal mediator of glucose-induced gene expression in the liver
L Ma, LN Robinson, HC Towle - Journal of Biological Chemistry, 2006 - ASBMB
In mammals, glucose-regulated gene expression has been best characterized in the liver,
where increased glucose metabolism induces transcription of genes encoding enzymes
involved in de novo lipogenesis. ChREBP and Mlx dimerize and function together as a
glucose-responsive transcription factor to regulate target genes, such as liver-type pyruvate
kinase, acetyl-CoA carboxylase 1, and fatty acid synthase. To identify additional glucose-
responsive genes in the liver, we used microarray analysis to compare gene expression …
where increased glucose metabolism induces transcription of genes encoding enzymes
involved in de novo lipogenesis. ChREBP and Mlx dimerize and function together as a
glucose-responsive transcription factor to regulate target genes, such as liver-type pyruvate
kinase, acetyl-CoA carboxylase 1, and fatty acid synthase. To identify additional glucose-
responsive genes in the liver, we used microarray analysis to compare gene expression …