[HTML][HTML] Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMP-activated protein kinase-endothelial nitric-oxide synthase …

Y Ikeda, K Aihara, S Yoshida, T Iwase, S Tajima… - Journal of Biological …, 2012 - ASBMB
We previously clarified that heparin cofactor II (HCII), a serine proteinase inhibitor, exerts
various protective actions on cardiovascular diseases in both experimental and clinical
studies. In the present study, we aimed to clarify whether HCII participates in the regulation
of angiogenesis. Male heterozygous HCII-deficient (HCII+/−) mice and male littermate wild-
type (HCII+/+) mice at the age of 12–16 weeks were subjected to unilateral hindlimb ligation
surgery. Laser speckle blood flow analysis showed that blood flow recovery in response to …