[HTML][HTML] PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

BN Finck, DP Kelly - The Journal of clinical investigation, 2006 - Am Soc Clin Investig
The Journal of clinical investigation, 2006Am Soc Clin Investig
Members of the PPARγ coactivator-1 (PGC-1) family of transcriptional coactivators serve as
inducible coregulators of nuclear receptors in the control of cellular energy metabolic
pathways. This Review focuses on the biologic and physiologic functions of the PGC-1
coactivators, with particular emphasis on striated muscle, liver, and other organ systems
relevant to common diseases such as diabetes and heart failure.
Members of the PPARγ coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.
The Journal of Clinical Investigation