[HTML][HTML] CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance [S]

JM Brown, JL Betters, C Lord, Y Ma, X Han… - Journal of lipid …, 2010 - ASBMB
Mutations of Comparative Gene Identification-58 (CGI-58) in humans cause triglyceride (TG)
accumulation in multiple tissues. Mice genetically lacking CGI-58 die shortly after birth due
to a skin barrier defect. To study the role of CGI-58 in integrated lipid and energy
metabolism, we utilized antisense oligonucleotides (ASOs) to inhibit CGI-58 expression in
adult mice. Treatment with two distinct CGI-58-targeting ASOs resulted in∼ 80–95%
knockdown of CGI-58 protein expression in both liver and white adipose tissue. In chow-fed …