[HTML][HTML] The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCFβ-TrCP E3 ligase
CY Liu, ZY Zha, X Zhou, H Zhang, W Huang… - Journal of Biological …, 2010 - ASBMB
The TAZ transcription co-activator promotes cell proliferation and epithelial-mesenchymal
transition. TAZ is inhibited by the Hippo tumor suppressor pathway, which promotes TAZ
cytoplasmic localization by phosphorylation. We report here that TAZ protein stability is
controlled by a phosphodegron recognized by the F-box protein β-TrCP and ubiquitylated by
the SCF/CRL1 β-TrCP E3 ligase. The interaction between TAZ and β-TrCP is regulated by
the Hippo pathway. Phosphorylation of a phosphodegron in TAZ by LATS primes it for …
transition. TAZ is inhibited by the Hippo tumor suppressor pathway, which promotes TAZ
cytoplasmic localization by phosphorylation. We report here that TAZ protein stability is
controlled by a phosphodegron recognized by the F-box protein β-TrCP and ubiquitylated by
the SCF/CRL1 β-TrCP E3 ligase. The interaction between TAZ and β-TrCP is regulated by
the Hippo pathway. Phosphorylation of a phosphodegron in TAZ by LATS primes it for …