[HTML][HTML] Proteomic and biochemical analyses of human B cell-derived exosomes: potential implications for their function and multivesicular body formation
R Wubbolts, RS Leckie, PTM Veenhuizen… - Journal of Biological …, 2003 - ASBMB
Exosomes are 60–100-nm membrane vesicles that are secreted into the extracellular milieu
as a consequence of multivesicular body fusion with the plasma membrane. Here we
determined the protein and lipid compositions of highly purified human B cell-derived
exosomes. Mass spectrometric analysis indicated the abundant presence of major
histocompatibility complex (MHC) class I and class II, heat shock cognate 70, heat shock
protein 90, integrin α4, CD45, moesin, tubulin (α and β), actin, G i α 2, and a multitude of …
as a consequence of multivesicular body fusion with the plasma membrane. Here we
determined the protein and lipid compositions of highly purified human B cell-derived
exosomes. Mass spectrometric analysis indicated the abundant presence of major
histocompatibility complex (MHC) class I and class II, heat shock cognate 70, heat shock
protein 90, integrin α4, CD45, moesin, tubulin (α and β), actin, G i α 2, and a multitude of …