During the orchestrated process leading to mature erythrocytes, reticulocytes must
synthesize large amounts of hemoglobin, while eliminating numerous cellular components.
Exosomes are small secreted vesicles that play an important role in this process of specific
elimination. To understand the mechanisms of proteolipidic sorting leading to their
biogenesis, we have explored changes in the composition of exosomes released by
reticulocytes during their differentiation, in parallel to their physical properties. By combining …