Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
I Fares, J Chagraoui, Y Gareau, S Gingras, R Ruel… - Science, 2014 - science.org
I Fares, J Chagraoui, Y Gareau, S Gingras, R Ruel, N Mayotte, E Csaszar, DJHF Knapp…
Science, 2014•science.orgThe small number of hematopoietic stem and progenitor cells in cord blood units limits their
widespread use in human transplant protocols. We identified a family of chemically related
small molecules that stimulates the expansion ex vivo of human cord blood cells capable of
reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The
potent activity of these newly identified compounds, UM171 being the prototype, is
independent of suppression of the aryl hydrocarbon receptor, which targets cells with more …
widespread use in human transplant protocols. We identified a family of chemically related
small molecules that stimulates the expansion ex vivo of human cord blood cells capable of
reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The
potent activity of these newly identified compounds, UM171 being the prototype, is
independent of suppression of the aryl hydrocarbon receptor, which targets cells with more …
The small number of hematopoietic stem and progenitor cells in cord blood units limits their widespread use in human transplant protocols. We identified a family of chemically related small molecules that stimulates the expansion ex vivo of human cord blood cells capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. The potent activity of these newly identified compounds, UM171 being the prototype, is independent of suppression of the aryl hydrocarbon receptor, which targets cells with more-limited regenerative potential. The properties of UM171 make it a potential candidate for hematopoietic stem cell transplantation and gene therapy.
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