[HTML][HTML] Protein stability and transcription factor complex assembly determined by the SCL-LMO2 interaction
E Lécuyer, S Larivière, MC Sincennes, A Haman… - Journal of biological …, 2007 - ASBMB
Gene expression programs are established by networks of interacting transcription factors.
The basic helix-loop-helix factor SCL and the LIM-only protein LMO2 are components of
transcription factor complexes that are essential for hematopoiesis. Here we show that
LMO2 and SCL are predominant interaction partners in hematopoietic cells and that this
interaction occurs through a conserved interface residing in the loop and helix 2 of SCL. This
interaction nucleates the assembly of SCL complexes on DNA and is required for target …
The basic helix-loop-helix factor SCL and the LIM-only protein LMO2 are components of
transcription factor complexes that are essential for hematopoiesis. Here we show that
LMO2 and SCL are predominant interaction partners in hematopoietic cells and that this
interaction occurs through a conserved interface residing in the loop and helix 2 of SCL. This
interaction nucleates the assembly of SCL complexes on DNA and is required for target …