Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus
AA Like, AA Rossini - Science, 1976 - science.org
AA Like, AA Rossini
Science, 1976•science.orgMultiple small injections of streptozotocin in mice produce pancreatic insulitis, with
progression to nearly complete beta cell destruction and diabetes mellitus. The timing and
appearance of the inflammatory islet lesions suggest but do not prove that streptozotocin
acts by initiating a cell-mediated immune reaction. Ultrastructural evidence of abundant type
C viruses within beta cells of treated mice suggests that streptozotocin may activate murine
leukemia virus in vivo in susceptible hosts.
progression to nearly complete beta cell destruction and diabetes mellitus. The timing and
appearance of the inflammatory islet lesions suggest but do not prove that streptozotocin
acts by initiating a cell-mediated immune reaction. Ultrastructural evidence of abundant type
C viruses within beta cells of treated mice suggests that streptozotocin may activate murine
leukemia virus in vivo in susceptible hosts.
Multiple small injections of streptozotocin in mice produce pancreatic insulitis, with progression to nearly complete beta cell destruction and diabetes mellitus. The timing and appearance of the inflammatory islet lesions suggest but do not prove that streptozotocin acts by initiating a cell-mediated immune reaction. Ultrastructural evidence of abundant type C viruses within beta cells of treated mice suggests that streptozotocin may activate murine leukemia virus in vivo in susceptible hosts.
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