[HTML][HTML] Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections
J Nikolich-Žugich - Nature Reviews Immunology, 2008 - nature.com
Nature Reviews Immunology, 2008•nature.com
A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious
defence against infection with new or re-emerging pathogens throughout life. In the last third
of the mammalian lifespan, the maintenance of a balanced T-cell repertoire becomes highly
challenging because of the changes in T-cell production and consumption. In this Review, I
question whether latent persistent pathogens might be key factors that drive this imbalance
and whether they determine the extent of age-associated immune deficiency.
defence against infection with new or re-emerging pathogens throughout life. In the last third
of the mammalian lifespan, the maintenance of a balanced T-cell repertoire becomes highly
challenging because of the changes in T-cell production and consumption. In this Review, I
question whether latent persistent pathogens might be key factors that drive this imbalance
and whether they determine the extent of age-associated immune deficiency.
Abstract
A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious defence against infection with new or re-emerging pathogens throughout life. In the last third of the mammalian lifespan, the maintenance of a balanced T-cell repertoire becomes highly challenging because of the changes in T-cell production and consumption. In this Review, I question whether latent persistent pathogens might be key factors that drive this imbalance and whether they determine the extent of age-associated immune deficiency.
nature.com