[HTML][HTML] High-content analysis of antibody phage-display library selection outputs identifies tumor selective macropinocytosis-dependent rapidly internalizing …

KD Ha, SM Bidlingmaier, Y Zhang, Y Su… - Molecular & cellular …, 2014 - ASBMB
Many forms of antibody-based targeted therapeutics, including antibody drug conjugates,
utilize the internalizing function of the targeting antibody to gain intracellular entry into tumor
cells. Ideal antibodies for developing such therapeutics should be capable of both tumor-
selective binding and efficient endocytosis. The macropinocytosis pathway is capable of
both rapid and bulk endocytosis, and recent studies have demonstrated that it is selectively
up-regulated by cancer cells. We hypothesize that receptor-dependent macropinocytosis …