[HTML][HTML] Distorted Relation between mRNA Copy Number and Corresponding Major Histocompatibility Complex Ligand Density on the Cell Surface* S

AO Weinzierl, C Lemmel, O Schoor, M Müller… - Molecular & Cellular …, 2007 - ASBMB
The major histocompatibility complex (MHC) presents peptides derived from degraded
cellular proteins to T-cells and is thus crucial for triggering specific immune responses
against viral infections or cancer. Up to now, there has been no evidence for a correlation
between levels of mRNA (the" transcriptome") and the density of MHC-peptide complexes
(the" MHC ligandome") on cells. Because such dependences are of intrinsic importance for
the detailed understanding of translation efficiency and protein turnover and thus for systems …