[HTML][HTML] Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I …
D de Verteuil, TL Muratore-Schroeder… - Molecular & Cellular …, 2010 - ASBMB
Proteasome-mediated proteolysis plays a crucial role in many basic cellular processes. In
addition to constitutive proteasomes (CPs), which are found in all eukaryotes, jawed
vertebrates also express immunoproteasomes (IPs). Evidence suggests that the key role of
IPs may hinge on their impact on the repertoire of peptides associated to major
histocompatibility complex (MHC) I molecules. Using a label-free quantitative proteomics
approach, we identified 417 peptides presented by MHC I molecules on primary mouse …
addition to constitutive proteasomes (CPs), which are found in all eukaryotes, jawed
vertebrates also express immunoproteasomes (IPs). Evidence suggests that the key role of
IPs may hinge on their impact on the repertoire of peptides associated to major
histocompatibility complex (MHC) I molecules. Using a label-free quantitative proteomics
approach, we identified 417 peptides presented by MHC I molecules on primary mouse …